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Triamcinolone acetonide use, side effect, Mechanism action and Dosage


What is Triamcinolone acetonide?

Triamcinolone acetonide is a synthetic corticosteroid. Nasal corticosteroids are cortisone-like medicines. They belong to the family of medicines called steroids. These medicines are sprayed or inhaled into the nose to help relieve the stuffy nose, irritation, and discomfort of hay fever, other allergies, and other nasal problems. These medicines are also used to prevent nasal polyps from growing back after they have been removed by surgery.

What is Triamcinolone acetonide used to treat?

Triamcinolone is a prescription drug to relieve symptoms of rhinitis. It is also used to prevent allergy symptoms including sneezing, itching, and runny or stuffed nose.
This drug is use for the treatment of joint pain, swelling and stiffness in an inflammatory disease like rheumatoid arthritis.
Triamcinolone acetonide Injection
Triamcinolone acetonide injection

This medicine is also used for the treatment of various allergic disorder including asthma, seasonal allergies, blood disorder, hormone the problem, rheumatic fever, disease related to the digestive system, kidney problem, lungs and skin.
Triamcinolone cream are also used for treat mouth sore very effectively.

Triamcinolone acetonide cream

Triamcinolone cream is an ointment that is used to a few different symptoms on your skin. These symptoms range from dryness and itching to redness and inflammation. All of these symptoms are based around discomfort you might feel from a rash or other skin condition you might have.
This drug can also be used to treat some different mouth sores. This cream and ointment can either be prescribed for certain conditions or you can find it over the counter in many drug stores. There is an emollient that protects the skin against dryness.
The cream is made of a combination of an emollient and a corticosteroid. The emollients keep the skin hydrated and not dry. The corticosteroid helps reduce an inflammation or irritation within the skin. The combination of the two together will help keep the skin feeling moisturized and comfortable.

What type of precaution take before use Triamcinolone acetonide?

Before you start using this triamcinolone acetonide cream or tablets or Injection there are a few things you should take into consideration. The first thing to think about before trying triamcinolone dosage form is what drugs you are currently taking. You need to make sure you keep your physician informed with any medications you are taking.

There are certain medications that might react negatively with the cream or tablet or Injection. If you have a history of any medication allergies, you should keep those in consideration as well.

Read the composition of dosage form for this cream and if you have had allergic reactions to any of the ingredients, you should stay away from this ointment.
There are many different medical ointments that contain corticosteroids. If you have ever had an allergic reaction to any of these medications, make sure you let your physician know so he can find a different ointment for your skin condition.

How to use Triamcinolone acetonide cream?

Triamcinolone is available in a few different dosage forms. The most common way to use this medication is in the cream. This will let your rub it into your skin as often as you need to. You will be able to rub the cream into your skin so you achieve the most moisture as possible.
Triamcinolone acetonide cream
Triamcinolone acetonide cream

The ointment version of this medication is almost like the cream. The ointment will be thicker than the cream which means you don’t need nearly as much for your dry skin. A little drop of the ointment will go a long way.

The ointment is also used for the sores that arise inside of your mouth. It won’t run all over your mouth and will stick to the sore spot instantly.

The lotion form is even thinner than the cream. You might need to use a little extra of the lotion form in order to have the moisture you desire. The liquid form is also used inside of the mouth. You can find the liquid in a bottle or an aerosol bottle. If you need to spray the medication you can do so with the aerosol version.

Before you use any of the forms of the triamcinolone cream, you should wash or soak the area that is infected very thoroughly. This will prevent any bacteria from getting into the infected area.

There are different ways this product should be used based on the form of the product you decide to use. If you decide to use the ointment form, also known as the paste form, you should apply it to your mouth sore. Instead of applying a large amount, use a little dot and don’t rub it in. once a film has developed over the mouth sore, you can start to rub the paste into the sore.

The larger your sore is, the more ointment and paste you will have to use. This form of the product is supposed to start working within a week. The lotion and the liquid forms are meant more for the scalp areas. You should part your hair where the rash is and apply a minimal amount of the lotion. It would be a good idea to keep from washing the infected area until the lotion has completely dried. The last form is the aerosol. Before you spray the area that has the infection, make sure you shake the aerosol container well.

With all of the forms of the triamcinolone cream, you should be able to get rid of any itching or redness you may have anywhere on your body. Just make sure you pay attention to any allergies you may have. If you have any worries about the lotion or cream you should consult with your primary care physician before using it

Side effect of Triamcinolone acetonide

Like other medicine Triamcinolone have some common and serious side effects are shown. But some side effect are different due to dose and different type of dosage form.

This drug have some minor, temporary and serious side effects. You must need some help of medical attention when you suffer serious side effect.
The most common Triamcinolone acetonide side effects are
Burning, dryness, or other irritation inside the nose for short time period. increase in sneezing and irritation of throat.

Most of the mild side effects may go away during treatment as the body adjusts to the Triamcinolone. However, only the doctor can determine the decision to buy specific dosages of this drug as also counsel treatment in the occurrence of Triamcinolone dosage side effects.
Some of the more serious Triamcinolone acetonide side effects are
Bad smell,
Blindness,
Bloody mucus or unexplained nosebleeds
Blurred or gradual loss of vision
Irritation inside nose after spray (continuing)
Crusting,
White patches,
Sores inside nose
Discharge or redness in eye, eyelid, or inner lining of the eyelid,
Eye pain,
Headache,
Hives,
Light-headedness,
Loss of sense of taste or smell,
Muscle pain,
Nausea or vomiting
Ringing in the ears
Shortness of breath
Skin rash
Sore throat, cough, or hoarseness
Stomach pains
Stuffy, dry, or runny nose or watery eyes (continuing),
Swelling of eyelids, face, or lips
Tightness in chest; troubled breathing
Unusual tiredness or weakness
Wheezing
White patches in throat.

Mechanism action of Triamcinolone acetonide

Triamcinoloneacetonide is a synthetic glucocorticoid, the mechanism of action of this drug is agonist the receptor and helps to translocation of the ligand receptor binding site.
Triamcinolone acetonide Structure
triamcinolone acetonide Structure

This drug inhibits the release of interleykina1, interleykina2, interferon gamma from lymphocytes and macrophages. Induces the formation lipokortina inhibits the release of eosinophil mediators of inflammation and stabilizes the membranes of fat cells. Has anti-inflammatory, antiallergic, anti-action. Reduces bronchial hyperreactivity, restores the sensitivity of receptors to beta-agonist, stabilizes mast cell membranes, reduces the number of mast cells, macrophages, T-lymphocytes and eosinophils in the epithelium and submucosal layer of bronchi.

At therapeutic doses, has almost no systemic action, does not inhibit the function of the adrenal cortex, does not cause delays Na + in the body and the appearance of edema. Increases glycogenesis, activate catabolic processes. Onset of action – within 12 hours, reaches a aximum at 4-7 days of therapy.

Pharmacokinetic of Triamcinolone acetonide

One study say when patients are take triamcinolone acetonide through intravenous 2 mg or oral 5 mg and inhaled 2 mg and check the plasma by the assay test we found half life of this drug is 2.0 hour and volume of distribution was 103 liter and clearance of body is 37 liter/hour.

Oral bioavailability is 23% when patients are take orally, absorption is rapid . in one hour 10.5 ng/ mL. Inhalation form bioavailability is 22% with maximum level rich in 2.0 ng/mL observed after 2.1 hour.

Dosage of Triamcinolone acetonide

Triamcinolone dosage levels should be determined only by the doctor. Dose of the drug is given 2.5 to 15 mg. Maximum dose is given upto 40 mg per day. Doctor prescribe the dose according to severity of infection. Triamcinolone comes either as a spray or used with an inhaler.

For nasal aerosol dosage form:
Adults and children 6 years of age and older (In some contry, children 12 years of age and older)-One or two sprays in each nostril once a day.
Children below 6 years of age Use and dose must be determined by the doctor.

For nasal suspension dosage form:
Adults and children 6 years of age and older-One or two sprays in each nostril one time a day. Children up to 6 years of age-Use and dose must be determined by the doctor.

Reference: Wikipedia, Pubchem, Drugs.com.




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