Rabeprazole Use, Side Effect, Mechanism Action, Interaction, Dosage and Other Information

Rabeprazole Use

Rabeprazole is used for treating ulcers of the stomach and duodenum, erosive or ulcerative gastroesophageal reflux disease (GERD) and Zollinger-Ellison Syndrome (in which there is an overproduction of acid caused by tumors). It also is used with antibiotics for eradicating Helicobacter pylori infections of the stomach that, along with acid, are responsible for many ulcers.
Doctor or pharmacist prescribes the Rabeprazole with some other medicine to reduce the acidity Because many drug stimulates the acid secretion gland. So when the patient takes the medicine to the intention of curing the disease unknowingly hyperacidity are from.
Rabeprazole Tablets 20 mg
Rabeprazole Tablets 20 mg

What is Rabeprazole?

It is a chemical entity use for the treatment of hyperacidity. It is not stable so salt from are available named as rabeprazole Sodium. Color is white to yellow and freely soluble in water, methanol, ethanol etc.

Rabeprazole Side Effects

Contemporary lifestyles of the young today rely on fast food and junk snacks that provide the least nutrition. What more, eating at graveyard/odd hours give rise to heartburns. There are many people suffering from heartburns and also gastrointestinal disorders and in Canada the doctors prescribe aciphex to alleviate the pain. This heartburn reliever can actually increase the heartburns if proper care is not taken under treatment. Aciphex side effects can be quite dangerous to different vital parameters of the body. The unpleasant response ranges from cardio vascular conditions, fluctuating BP levels, respiratory problems, and different kinds of allergies.
Aciphex, or rabeprazole, widely available in any Canada and other drug store and is administered orally for treatment of excess acid secretion in stomach. This belongs to the family of drugs that are named proton pump inhibitors or PPI in short. These drugs reduce secretion of acid by the stomach. Hence used for treating stomach ulcers, Zollinger-Ellison syndrome and Gastro esophageal reflux diseases. There is another cause of ulcers named Helicobacter pylori and Aciphex is used to take this out of the system too.

Common side effects of Rabeprazole sodium

The common effects are
·        Diarrhea
·        Vomiting
·        Rashes
·        Nausea  
·        Headaches
Some reactions are seen in mild form like nervousness, muscle cramp or leg cramps, weakness and dizziness and abnormal heart beat. While using this medication, if these symptoms are experienced on regular basis – it would be wise to discuss with the medical practitioner. In most patients the drug is mostly tolerated and does not give out many side effects. But in situation wherein the drug is being taken for more than a year in a high dose, may lead to osteoporosis.
The human body shows gastrointestinal effects by prolonged use of this drug, symptoms  like
·        Gastroenteritis
·        Flatulence
·        Constipation
·        Rectal hemorrhage
·        Mouth ulceration
·        Cholecystitis  
Some rare occurrences include cholangitis, salivary gland enlargement or duodenitis.  Intake of Rabeprazole for a long duration also has shown effects on the nervous system. Patients have experienced depression, anxiety, neuralgia, convulsion, vertigo, abnormal dreams and decreased libido and even tremor of the limbs. Few people have been detected with these issues which are the resultant of intake of this drug. Some of the rare complain are also noted by the physicians, like amnesia and hyperkinesia and even numbness of the hands and facial muscles. There has been weight gain and gout complaint also. Allergic reactions and face edema in the zone of hypersensitivity has also been reported in trials. People have complained of hematological effects and cardiovascular effects due to this composition.
Some side effects need to detail in consultation with the physician. Drinking lots of water to flush the system, vitamins and green tea and fresh fruits and other food that contain dietary fiber can also help. Toast, saltine crackers and ginger ale are sometimes good for diet and a few minutes of stretching exercises can also give relief. To buy it from any Canadian pharmacy, look up this vital information. Order it only when fully satisfied with the price, brand and delivery options are clear. 

Mechanism of action

Mechanism: Rabeprazole Sodium is mainly use for the treatment of high acidic condition in the body. It is Other wise known as antisecretory drug and it other wise known as proton pump inhibitors or PPIs.
According to invitro study in animal it concluded that it helps to block the proton pump to secretion of acid in stomach. It inhibit the secretion of gastric acid final stage of acid secretion at the final stage from the partial cells.
There are many other medicine working in the same ways include lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), and esomeprazole (Nexium).
According to Invitro study in the animal Rabeprazole is 2-10 time more flexible than omeprazole and it is easily separate out from the binding site of H+ and K+ ATPase as compare to Omeprazole within the short time period.so the side effect is less. Rabeprazole is bind with plasma protein reversible.
One the study said that Rabeprazole bind with H+ and K+ ATPase within 5 minutes with domestic pig gastric mucosa. Continuously taking of this medicine can increase the plasma serum level in the human body.
Rabeprazole also helps to reduce the gastric lesion and also helps to reduce the mucosal leukotriene of C4 and D4.
Like other anti gastric medicine this drug did not suppress the collagen generation or delay the healing of gastric lesion.
Due to blocking or secreting of acid in the stomach it is easy to  heal the stomach ulcer.
Rabeprazole sodium Structure
Rabeprazole sodium Structure

Pharmacokinetics of Rabeprazole Sodium

Oral dose of rabeprazole sodium is approximately 52% of the drug are circulate in the bloodstream. Among them, 97 % of the drug is bound in the plasma protein. The plasma half-life of a single dose is 1 hour and it takes 3.5 hours to achieve plasma pick concentration.
Rabeprazole is metabolized by the liver. The enzyme is responsible for metabolizing are CYP2C19 and CYP3A4. 90 % of the drug is metabolized by the liver and excreted by urine and 10% of the drug are excreted by faces.
This drug is converted into 4 different substitutes at the time of metabolism like thioether carboxylic acid, sulfone metabolites, mercapturic acid and dimethyl derivatives.

How to store Rabeprazole sodium?

Rabeprazole Sodium is hygroscopic material so it easily absorbed the moisture. For the container pack, medicine is store in cool and dark place and keep away from the children. The blister pack has no effect humidity but you must keep in a cool place for a long time.

Rabeprazole Dosage

There are various myths related to stomach illness. Most diagnosed gastro connected symptoms at some time need rabeprazole dosage to treat stomach problems. Some people recover and some do not despite having the prescribed dosage.
Every one’s Prienciple is different from the other, some people are bound to take some measured quantities of the drug for a longer period in combination of other value added medication. In normal circumstances when the patient complains of pains, acidity and heartburn in the night after dinner, many symptoms manifest, leading to ulcers and GERD. To combat the sick stomach, Canada drugs like Aciphex is advised in various doses depending on the gender, age and other related complications.
If it is clear that the patient has Gastro esophageal Reflux Disease or GERD, then Aciphex dosage is recommended for a mandatory 8 weeks. This drug heals the erosive GERD and reduces the rate of relapse of the heartburn. The 8 week course may not completely heal the patient and then another cycle is suggested by the physician. The Duodenal Ulcers also need this same drug but for a short period of time. This Ulcer must be healed by use of the drug for 4 weeks of treatment and the patient starts getting relief within that period. An adult should take a dosage of oral tablets of 20mg for GERD, and the tablet should be taken once for 4 – 8 weeks.

Dosage for Zollinger-Ellison syndrome

Rabeprazole sodium is also used for the treatment of the hypersecretory condition. It is referred as Zollinger-Ellison syndrome. The hypersecretory conditions differ in different person and the dose for this is 60mg at one time of the day and this can be slightly changed as per the condition and variance of the patient’s need. Some need to take the same quantity, for more than once and some need to take up to 100mg in a day and for some the dosage continues for a year. These drugs are available over the world with various brand name pharmacy stores-online and offline.
The medicine Aciphex 20mg is an enteric coated tablet, light yellow in color. The name is printed on the side and bottles of 30 and 90 are available and blister packs are also there in the market. The tablets should be kept in a place where there is no moisture. The elderly patients sometime need adjustment of the dosage. But the patients with renal failure or mild hepatic problem can take the prescribed quantity without side effects. However those who severe hepatic problems need to be cautious of any side effects or adverse reactions.
The side effects of this drug are never too severe and a few cases of stomach upset and insomnia or rashes and headache have been experienced by few. There might be people with special physical condition who may experience more severe effects and need to consult their doctors. The people allergic to rabeprazole or similar drugs need not use Aciphex or rabeprazole sodium. The tablets prescribed need to be swallowed and not chewed or crushed for intake. It can be taken with or even without meals as this has no affect on the body. If there is an overdose – care should be taken to consult the doctor. There has been no cases reported of large overdoses or any serious symptoms related to the overdose.

Precaution Before taking Rabeprazole Sodium

Aciphex falls within the group of PPI medicines and these can easily affect the hip bone, wrist and even spine.
It can cause serious fractures. The doctor’s permission must be taken to alter any quantity. Before administration, a consultation with the doctor is a must.
Pregnancy and or liver conditions need to be reported before consuming Aciphex for ulcers in stomach and esophagus. Those who have fluctuating blood levels need to be wary of this remedy also. The blood contains magnesium. Hypomagnesemia may occur on wrong dosage of this medicine. It can cause muscle spasm and seizures. Doctors need to keep a check on it. This drug must also not be taken with other medicines without the knowledge of the physician.
One must also take precautions against taking it with other street drugs or when alcohol intake is high. Doctor mainly prescribe this medicine to patients who had GERD.
After a long treatment showed no pathological changes in the mucosa but this happened with patients who had no H.pylori infection. But those patients with H.pylori infection showed inflammation in the gastric body or antrum. This inflammation occour in less percentage of patients but This remedy caused them intestinal metaplasia.

Interactions

There are two types of Interactions are shown in case of rabeprazole sodium tablets
·        Drug-drug Interactions
·        Food-drug Interactions

Drug-drug Interaction

Many other drugs like theophylline, warfarin, diazepam, phenytoin are reduce the metabolism of Rabeprazole. Because the same enzyme helps to metabolism of the drug.
These drug competitively binds with cytochrome subdomain and reduce the activity of the rabeprazole sodium.

This medicine suppresses the acid secretion so drug which are required an acidic medium for the metabolism they are not affected. Like digoxin, ketoconazole.
Clopidogrel and anticoagulant are interacting with this class of medicine.    
If the patients are taking rabeprazole  sodium with rilpivirine, it lowers the plasma concentration of rilpivirine. So chances of HIV Infection is more.

Food-drug Interaction

This drug is no effect to food but if the patients are taking this after food its effects are may delay. Do not eat the oily and spicy food if you take this medicine.

Reference 
Rabeprazole Use, Side Effect, Mechanism Action, Interaction, Dosage and Other Information Rabeprazole Use, Side Effect, Mechanism Action, Interaction, Dosage and Other Information Reviewed by aboutmedicine on 21:25 Rating: 5

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