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Indomethacin Use, Side Effect, Interaction and Treatment of Gout

Indomethacin Uses

Indomethacin is traditional NSAIDs which is comes under nonselactive COX inhibitor. This medicine is indole acetic acid derivative. Indomethacin is use for reducing the elevated body temperature. it also use in antiinflammatory action and reduce the pain only related to tissue injury. it is highly potent medicine. 

Indomethacin for Relieve Gout Pain

One of the most widely used drugs to eliminate gout pain and swelling is Indomethacin (often sold under the brand name Indocin). It is classified as a Non-Steroidal Anti-Inflammatory Drug (NSAID).
Other NSAIDs are used effectively to manage gout symptoms but Indomethacin is one of the three primary NSAIDS that has been approved to treat gout by the U.S. Food And Drug Administration.
Indomethacin is a powerful drug that effectively blocks inflammation in the body. If it is taken as directed it will improve the pain and swelling that is associated with gout attack symptoms. Be certain to consult with your doctor before taking any medications and stop taking them once your symptoms are brought under control. If you have any other health problems, it’s important to consult with your doctor.
Indomethacin capsule use for the treatment of gout
Indomethacin capsule 

Indomethacin Possible Side Effects

Possible side effects from taking Indocin or Indomethacin may include:

  • stomach upset
  • heartburn
  • headache
  • fatigue
  • drowsiness
  • dizziness 
Tell your doctor immediately if any of these unlikely but serious side effects occur:

  • Stomach pain
  • Swelling of the hands/feet
  • Sudden/unexplained weight gain
  • Vision changes
  • Hearing changes (e.g., ringing in the ears)
  • Changes in mental condition
  • Increased heart rate
  • Persistent severe headache
  • Fainting
  • Muscle weakness
  • Uncontrolled movements
  • Difficult or painful swallowing
Some rare but very serious side effects may occur:

  • Change in the amount of urine
  • Easy bruising/bleeding
  • Signs of infection (e.g., fever, persistent sore throat)
  • Unexplained stiff neck
  • Seizures  
This drug may rarely cause serious and possibly fatal liver disease.  If you notice any of the following rare but very serious side effects, stop taking this medication immediately and call your doctor: yellowing eyes/skin, dark urine, unusual/extreme fatigue, severe abdominal pain, persistent nausea or vomiting.  Symptoms of a rare but serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness or trouble breathing and you should seek emergency medical assistance immediately.

Indomethacin Warnings and Precautions

Prior to taking Indocin or Indomethacin, inform your doctor or pharmacist if you are allergic to it, other NSAIDs, aspirin or any other medication.

This medication should not be used if you have certain medical conditions so be sure to consult your doctor or pharmacist if you have aspirin-sensitive asthma, kidney disease, or a recent heart bypass surgery or of any medical conditions you may have.

This drug may cause dizziness so it is important not to drive, use machinery, or do any activity that requires alertness until you are fully alert.  Also be sure to inform your doctor or dentist that you are using this drug before having any type of surgery.

The use of alcohol and tobacco is not advised while taking this drug as it may increase your risk for stomach bleeding.   Indocin may make you more sensitive to the sun so prolonged sun exposure should be avoided and a high SPF sunscreen should be used before going outdoors.  Because this drug may be passed into breast milk, breastfeeding while using this drug is not recommended.
Indomethacin Structure
Indomethacin Structure

Indomethacin drug Interactions

As with any prescription drug, possible drug interactions may occur when using Indocin or Indomethacin, so be sure to consult with your healthcare professional about any possible drug interactions.  This drug should not be used with certain drugs and herbs such as Cidofovir, other NSAIDs (e.g., Diflunisal, Ketorolac), high doses of aspirin and related drugs and diuretics because very serious interactions may occur.  If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting Indomethacin.
Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: anti-platelet drugs, blood thinners, corticosteroids, high blood pressure drugs, receptor and/or beta-blockers, potassium supplements, SSRI antidepressants and diuretics.  This medication can affect the results of certain lab tests always inform your medical professionals of any medications you are taking.

Indomethacin Dose for Treatment of Gout

For the vast majority of gout patients, non-steroidal anti-inflammation drugs are an extremely successful gout treatment and rapid gout remedy. The FDA has conducted tests on a wide variety of NSAIDs but has only approved the following for treatment of acute gout symptoms:
Indomethacin: Should not use in excess of two days. Avoid taking more than 200mg per day without consulting your physician.
Naproxen: Avoid dosage in excess of 750 mg on day one. Discontinue use after ten days unless directed by your physician.
Sulindac: Avoid dosage in excess of 400mg per day. Discontinue use after seven days unless directed by your physician
 The overwhelming benefits of these particular NSAIDs include rapid gout relief. Indomethacin has shown relief in some cases within two to four hours after the onset of acute gout symptoms. They are better tolerated and less toxic to gout patients when properly prescribed. They are well known and respected drug treatments and are relatively inexpensive to the consumer.

What is a gout attack?

Even the word “attack” suggests a dangerous situation. A typical gout attack will follow a prolonged period of uric acid build up in the blood. This is called asymptomatic hyperuricemia, a high blood uric acid level.
This build up initially revolves around a single joint. For nearly 50% of gout patients, the big toe is usually the focus of their first full on gout attack. Gout also affects ankles, heels and knees but it’s the late night big toe attack that has earned gout it’s painful reputation.
UpToDate, a trusted physician’s reference used by those seeking in-depth and well-explained medical information describes a gout attack as follows:
“Gout attacks cause sudden severe joint pain, sometimes with redness, swelling, and tenderness of the joint. Although an attack typically affects a single joint, some people develop a few inflamed joints at the same time. The pain and inflammation are worst within several hours, and generally improve completely over a few days to several weeks, even if untreated. It is not clear how the body “turns off” a gout attack.”

What does a gout attack feel like?

A gout attack often begins with a twinge of pain. This pain increases rapidly to a much more severe level and continues steadily from eight to twelve long hours. It’s usually focused around a single joint but there are many cases where multiple joints become involved. Approximately half of all patients experience severe pain and swelling in their big toe but as we mentioned earlier other joints can be affected as well.

How often do gout attacks occur?

If left untreated, a mild gout attack may only last a few hours. The most severe cases, however may drag on for one or two weeks. In the earliest stages there might be weeks, months or even years between gout attacks. Over an extended period of time however, they can occur more frequently, last longer and cause more severe pain and discomfort.

How to Cure Gout Disease Fast ?

Indomethacin should be taken as soon as initial gout symptoms begin. The more quickly you start your Indomethacin gout medicine regimen the sooner you can expect relief. Indomethacin is a powerful NSAID that is used to relieve the severe pain, tenderness and swelling that accompanies each gout attack.
Take Indomethacin exactly as directed. Consult your doctor if have questions about your medication.


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