The drug is basically used for treating
rheumatic complaints and specifically gout. The medication was also prescribed
for its healing and emetic effects. However, currently, this drug is use for
medicinal treatments of gout in special besides the drug is being studied for
its potential use as the anti-cancer medication. Colchicine can also be use as
the primary treatment for pericarditis and averting repetitions of such
Use of colchicine for the Treatment of Gout
the condition of acute gout there is a noticeable inflammatory response to the
presence of uric acid crystals which causes severe pain, redness and swelling
of the affected joints. Colchicine is highly effective in suppressing such
inflammation in the acute gout conditions. Colchicine is usually manufactured
in tablet form of 5mg and 6mg dosage strengths as well as in the intravenous
injectable forms. The
recommended doses of this medication should be taken with food. Colchicine is
mainly used for treating the acute flares of gouty arthritis and averts its
recurrences. The drug is also used for treating the inflammation of pseudo-gout
and certain other rare ailments like familial Mediterranean fever, amyloidosis,
and scleroderma. Colchicine could be order online for intending patients while
it is widely available in the USA, Canada, UK, and Australia.
Colchicine side effects
is the highly poisonous natural product and derived metabolite. It is extracts
from the plants belonging to the species called Colchicum or Autumn Crocus.
Initially the drug was using for treating rheumatic disorders particularly the
gout condition. Though, the current medicinal use of the drug is for treating
gout, possibilities of its use for treating cancer are well under studies. The
drug is using for helping relieve the acute pains of gout attacks and avert its
recurrences as well. Like all other medicines, Colchicine may also cause
certain side effects ranging from mild to severe. Some of such reported side
Blood accompanying urine
Weakness in muscles
Itching in hands or feet
Difficulty while passing urine
Irritation at the injection site on the body
Skin rash or itching
Swelling of the face or mouth,
Unusual bruising or bleeding and unusual weakness or exhaustion.
any such symptoms or experiences, the patient should immediately refer to his
doctor for necessary medical help. But, the patient may experience some other
side effects for which patients may not require consulting the doctor side
effects are automatically goes away after stop the take medicine.
loss of appetite and hair loss.
more but rare signs of side effects that are unexpecting or uncommon may in
some remote cases be report by the patients for which they are tell to consult
his doctor on priority for necessary medical advice and actions.
symptoms of gout can be minimize, if not totally eliminated without the harsh
side effects of colchicine, or the dangers of NSAID pain relievers and
corticosteroids once and for all!
you relate with any of these symptoms?
Intense pain in the joints (often the big toe).
The feeling of heat or throbbing in the joints
Joint swelling and redness.
Allodynia (extreme pain to the touch).
Sudden, acute attacks of arthritis.
affects nearly 60 million people worldwide, particularly men over 35, though
women over 50 are particularly susceptible.
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Mechanism of action colchicine
Colchicine is the brand medication approve by
the Food and Drug Administration-FDA for the treatment of gout. This medicine
are good for familial Mediterranean fever, minor amyloidosis and scleroderma.
The drug is also used as the anti-inflammatory agent for long-term treatment of
is typical indicated for the treatment and relief of pain in the attacks of
acute gouty arthritis.
you are more curiosity about How does
colchicine work ? read continue
medication is also wide recommended for regular use between attacks as the
prophylactic measure and is often effective in terminating the attack if taken
at the initial sign of articular discomfort.
precise mechanism of action of Colchicine in gout is not yet thoroughly known
but it involves the decrease in lactic acid production by leukocytes. which
lead to reduction in uric acid deposition besides reducing phagocytes with
abatement of the inflammatory response. In spite of help relieving pain in the
acute attacks of gout, Colchicine is neither an analgesic nor the uricosuric
agent and does not prevent progression of gout in chronic gouty arthritis
conditions. The drug has the prophylactic, suppressive efficacy which helps
decreasing the episodes of acute attacks and relieves the remaining pain and
mild discomfort that the patients suffering from gout infrequently experience.
is absorbe faster after its oral ingestion and most amount of this medication
and metabolites enter the intestinal tract in the bile and intestinal
concentrations of Colchicine found in the kidney, liver and spleen. The drug is
not tightly bound to serum protein so it quickly leaves the bloodstream.
Secretion arises initially by biliary and renal routes. The drug is prescribing
based on certain pathological tests suggested by the doctor before initiating
Over dose of colchicine
Symptoms of a colchicine overdose include
nausea; vomiting; stomach pain; diarrhea; muscle weakness; burning in your
throat, stomach, or skin; difficulty breathing; delirium; and seizures. An
overdose of colchicine can result in death. If you suspect an overdose, seek
immediate medical attention.
your doctor and pharmacist about all the medicines that you are taking.
Colchicine may interact with other drugs.
History of Colchicine
Colchicine the branded prescription medicine
which is formally approved by the Food and Drug Administration – FDA for the
treatment of gout, familial Mediterranean fever, secondary amyloidosis and
scleroderma disorders. The side effects of this medication include
gastrointestinal effect on mitosis upset and Colchicine plus molecular formula
to take Colchicine right from the early stage of gout attacks can help
aggravate the symptoms. Higher doses may also damage bone marrow and lead to
anemia. Particularly it restrains the growth of
spindles as the nuclei are dividing. Generally the cell use its spindle fibers
for lining up its chromosomes, imitate them and divide into the two new cells
with each daughter cell having the single set of chromosomes.
presence of Colchicine prevents them to form leading the cells unable to move
their chromosomes around. The cells may end up copying some or all the
chromosomes but cannot transmit them out into the new cells and thus they never
divide anymore. Since cancer cells divide much faster as compared to the normal
cells, cancers are more at risk of being poisone by mitotic inhibitors like
Colchicine. Anyway, Colchicine has proved of having the considerably narrow
range of effectiveness as the chemotherapy agent, hence it is the only Food and
Drug Administration – FDA approved use of treating gout though it is also at times
used in the veterinary medicines for treating cancer in some animals.
Colchicine is also used as the anti-mitotic agent in cancer research that
entails cell cultures.
How to take colchicine?
medicine is take with water. Some time patient are taking the medicine with
fruit juice but colchicine are producing side effect if you take this medicine
take the advice of doctor to taking medicine.
Why colchicine is taking less amount of dose?
extracted form the plants Colchicum Autumnale or Autumn Crocus which is poisons
plant. so colchicine are given less quantity to treatment of gout disease.
How to take colchicine for acute gout?
for the gout disease is 2 tablets after 1 tablets take for the 12 hours. or you
can take 3 tablets in a day. take doctor advice for better treatments. Medicine
are taking after eating some food.
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