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Colchicine: Use, Side Effect, Mechanism action and Other Information


Introduction about colchicine

Colchicine are available in the market as branded medicine which is manufacture by generic active ingredient called Colchicine, which is mostly useful for the treatment for the gout disease.
 
Colchicine Tablets
Colchicine Tablets
Colchicine is poisonous natural product and derive metabolite extracted from plants of species called Colchicum Autumnale or Autumn Crocus which are also known as the ‘Meadow Saffron’

Colchicine use

The drug is basically used for treating rheumatic complaints and specifically gout. The medication was also prescribed for its healing and emetic effects. However, currently, this drug is use for medicinal treatments of gout in special besides the drug is being studied for its potential use as the anti-cancer medication. Colchicine can also be use as the primary treatment for pericarditis and averting repetitions of such episodes.

Use of colchicine for the Treatment of Gout

In the condition of acute gout there is a noticeable inflammatory response to the presence of uric acid crystals which causes severe pain, redness and swelling of the affected joints. Colchicine is highly effective in suppressing such inflammation in the acute gout conditions. Colchicine is usually manufactured in tablet form of 5mg and 6mg dosage strengths as well as in the intravenous injectable forms. 

The recommended doses of this medication should be taken with food. Colchicine is mainly used for treating the acute flares of gouty arthritis and averts its recurrences. The drug is also used for treating the inflammation of pseudo-gout and certain other rare ailments like familial Mediterranean fever, amyloidosis, and scleroderma. Colchicine could be order online for intending patients while it is widely available in the USA, Canada, UK, and Australia.

Colchicine side effects

 

Colchicine is the highly poisonous natural product and derived metabolite. It is extracts from the plants belonging to the species called Colchicum or Autumn Crocus. Initially the drug was using for treating rheumatic disorders particularly the gout condition. Though, the current medicinal use of the drug is for treating gout, possibilities of its use for treating cancer are well under studies. The drug is using for helping relieve the acute pains of gout attacks and avert its recurrences as well. Like all other medicines, Colchicine may also cause certain side effects ranging from mild to severe. Some of such reported side effects include:


1. Blood accompanying urine
2. Difficulty breathing
3. Fever
4. Chills
5. Sore throat
6. Weakness in muscles
7. Nausea
8. Vomiting
9. Numbness
10. Itching in hands or feet
11. Pain
12. Difficulty while passing urine
13. Swelling
14. Redness
15. Irritation at the injection site on the body
16. Skin rash or itching
17. Stomach pain
18. Swelling of the face or mouth,
19. Unusual bruising or bleeding and unusual weakness or exhaustion.

In any such symptoms or experiences, the patient should immediately refer to his doctor for necessary medical help. But, the patient may experience some other side effects for which patients may not require consulting the doctor side effects are automatically goes away after stop the take medicine.
1. Diarrhea
2. loss of appetite and hair loss.
Some more but rare signs of side effects that are unexpecting or uncommon may in some remote cases be report by the patients for which they are tell to consult his doctor on priority for necessary medical advice and actions.
Other symptoms of gout can be minimize, if not totally eliminated without the harsh side effects of colchicine, or the dangers of NSAID pain relievers and corticosteroids once and for all!

Can you relate with any of these symptoms?
- Intense pain in the joints (often the big toe).
- The feeling of heat or throbbing in the joints
- Joint swelling and redness.
- Allodynia (extreme pain to the touch).
- Sudden, acute attacks of arthritis.

Gout affects nearly 60 million people worldwide, particularly men over 35, though women over 50 are particularly susceptible.
Here’s a little look inside this exciting new report:
- The 7 best alternative treatments for gout.
- How “fad diets” can be worsening your gout problem.
- A proven sleep solution which could, by itself, eliminate your suffering!
- A step-by-step system to relieve your gout using safe, natural, proven home remedies.
- A diet to eliminate foods high in purines
- Supplementation of your diet with gout-fighting herbs and vitamins.
- Much, much, more.

Mechanism of action colchicine

Colchicine is the brand medication approve by the Food and Drug Administration-FDA for the treatment of gout. This medicine are good for familial Mediterranean fever, minor amyloidosis and scleroderma. The drug is also used as the anti-inflammatory agent for long-term treatment of Beh├žet’s disease.
Gout Disease Mechanism
Gout disease

Colchicine is typical indicated for the treatment and relief of pain in the attacks of acute gouty arthritis.
If you are more curiosity about How does colchicine work ? read continue
This medication is also wide recommended for regular use between attacks as the prophylactic measure and is often effective in terminating the attack if taken at the initial sign of articular discomfort.
The precise mechanism of action of Colchicine in gout is not yet thoroughly known but it involves the decrease in lactic acid production by leukocytes. which lead to reduction in uric acid deposition besides reducing phagocytes with abatement of the inflammatory response. In spite of help relieving pain in the acute attacks of gout, Colchicine is neither an analgesic nor the uricosuric agent and does not prevent progression of gout in chronic gouty arthritis conditions. The drug has the prophylactic, suppressive efficacy which helps decreasing the episodes of acute attacks and relieves the remaining pain and mild discomfort that the patients suffering from gout infrequently experience.

Colchicine is absorbe faster after its oral ingestion and most amount of this medication and metabolites enter the intestinal tract in the bile and intestinal secretions.
High concentrations of Colchicine found in the kidney, liver and spleen. The drug is not tightly bound to serum protein so it quickly leaves the bloodstream. Secretion arises initially by biliary and renal routes. The drug is prescribing based on certain pathological tests suggested by the doctor before initiating the treatments.

Over dose of colchicine


Symptoms of a colchicine overdose include nausea; vomiting; stomach pain; diarrhea; muscle weakness; burning in your throat, stomach, or skin; difficulty breathing; delirium; and seizures. An overdose of colchicine can result in death. If you suspect an overdose, seek immediate medical attention.
Tell your doctor and pharmacist about all the medicines that you are taking. Colchicine may interact with other drugs.

History of Colchicine


Colchicine the branded prescription medicine which is formally approved by the Food and Drug Administration – FDA for the treatment of gout, familial Mediterranean fever, secondary amyloidosis and scleroderma disorders. The side effects of this medication include gastrointestinal effect on mitosis upset and Colchicine plus molecular formula neutropenia.
Initiating to take Colchicine right from the early stage of gout attacks can help aggravate the symptoms. Higher doses may also damage bone marrow and lead to anemia. Particularly it restrains the growth of spindles as the nuclei are dividing. Generally the cell use its spindle fibers for lining up its chromosomes, imitate them and divide into the two new cells with each daughter cell having the single set of chromosomes.


The presence of Colchicine prevents them to form leading the cells unable to move their chromosomes around. The cells may end up copying some or all the chromosomes but cannot transmit them out into the new cells and thus they never divide anymore. Since cancer cells divide much faster as compared to the normal cells, cancers are more at risk of being poisone by mitotic inhibitors like Colchicine. Anyway, Colchicine has proved of having the considerably narrow range of effectiveness as the chemotherapy agent, hence it is the only Food and Drug Administration – FDA approved use of treating gout though it is also at times used in the veterinary medicines for treating cancer in some animals. Colchicine is also used as the anti-mitotic agent in cancer research that entails cell cultures.

How to take colchicine?
This medicine is take with water. Some time patient are taking the medicine with fruit juice but colchicine are producing side effect if you take this medicine with juice.
Always take the advice of doctor to taking medicine.

Why colchicine is taking less amount of dose?


Colchicine extracted form the plants Colchicum Autumnale or Autumn Crocus which is poisons plant. so colchicine are given less quantity to treatment of gout disease.

How to take colchicine for acute gout?
Dose for the gout disease is 2 tablets after 1 tablets take for the 12 hours. or you can take 3 tablets in a day. take doctor advice for better treatments. Medicine are taking after eating some food.

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