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Doxepin Use, Side Effects, Mechanism of action and other Information

Doxepin Use

Doxepin is mainly used for the treatment of Insomnia and depression. This medicine is class
of tricyclic antidepressant. Those people are feeling sad, tearful, not enjoy life as, like
normal people, they must take this medicine to feel better and enjoy life.
Doxepin Tablets
Doxepin Tablets
Image form Flickr



Those people are not getting well sleep due to depression they can take this medicine to get
good sleep.


This medication helps to relieve anxiety and tension. Ultimately helps to increase the energy
level in the body.


Major depression sign and symptoms are sad moods, loss of interest and pleasure, low
energy, worthlessness, guilt, psychomotor retardation, loss of appetite, loss of sleep, suicidal
thought.


Who are not able to take Doxepin ?
  • Those people are allergic to tricyclic antidepressant.
  • Those people are suffering the severe liver problem.
  • Eye problem like glaucoma.
  • Difficulty in urine problem
  • Breastfeeding
  • If patients are taking Monoamine oxidase inhibitor
  • Those people are suffering mania disorder
  • Below the 12 year age group


Doxepin Side Effects

Suicidal activity or Killing him shelf
Those people having thought like suicidal, if those people continue this medicine there are chances of increase suicidal thought.


So this type of patient starts the medication under the supervision of medical practitioner or contact with doctor.


Those people are taking this medication there are many chances of Bone fracture.


Some common side effect is Drowsiness, constipation, Dryness of mouth.


Some other common side effects are listed below


  1. Dizziness
  2. Sweating
  3. Blurred vision
  4. Headache
  5. Insomnia
  6. Difficulty in the urination
  7. Weakness
  8. Tiredness
  9. Weight gain
  10. Upset stomach
  11. Loss of appetite
  12. Vomiting
  13. Diheroia
  14. Heartbeat increase
  15. Loss of mouth taste
  16. Decrease Stamina
  17. Flushing
  18. Hair loss
  19. Numbness in hand and feat
  20. Feeling pinch of the pin in the body
  21. Confuse

Doxepin Mechanism of Action

In the Normal people, serotonin and Norepinephrine and Dopamine are playing the Importance
role in affecting bipolar diseases like mania and depression.
These amines are also responsible for regulating postsynaptic neuron that leads to depression
. Monoamine hypothesis causing stimulating abnormal gene that leads to depression.
Doxepin Mechanism of action
Doxepin Mechanism of action


Doxepin come under Tricyclic antidepressant. Which helps to prevent reuptake of
neurotransmitter.


Tricyclic antidepressant (Doxepin) blocks the serotonin Reuptake transporter .so there
are many chances of binding of a neurotransmitter to a receptor.


TCA also block ɑ receptor, histamine receptor, and muscarinic receptor. Due to the blocking of
these receptor Doxepin show some side effect.


When Serotonin, Norepinephrine and dopamine concentration is decreased there are many
chances of depression occur.


Serotonin helps to prevent Obsession and compulsions.
Norepinephrine is helping to prevents anxiety and attention.


Dopamine helps to maintain attention, motivation, and pleasure.


Serotonin helps to regulate the other two neurotransmitters.


Patients taking doxepin along with good environmental factor can help to prevent
depression.
Other medicine amitriptyline has the same mechanism of action.

Doxepin pharmacokinetic

Oral absorption of doxepin is well. So this medicine is available in the market as tablets
and capsule form. This medicine is highly bound with plasma protein and tissue protein.


The volume of distribution is 20 L/kg. this medicine are metabolism in the liver. Cytochrome
an enzyme is responsible for the metabolism of the doxepin.
Some cytochrome Isoenzyme like CYP2D6, CYP3A4, CYP1A2 and other.


This medicine is excreted through urine over 1-2 weeks. Plasma t1/2 of doxepin are
16-24 hours.


Doxepin Interaction

When you take this medicine it producing sleepness. So don’t take this medicine at the timeof driving or when you travel.
This medicine may interact with other groups of medicine like selective serotonin
 Reuptake inhibitor. so before you take this medicine you must contact your doctor.


Doxepin also interact with other drugs like citalopram, escitalopram, fluoxetine, fluvoxamine,
paroxetine, sertraline.

Doxepin Dosage



When you start taking this medicine it takes 2-3 weeks to show action.
Doxepin is available in the market mainly three dosage form like tablets, capsule and oral
liquid form.


Nowadays Doxepin Cream is available in market Neurocream 30 gm manufacture by aristo
pharmaceutical.


Doxepin capsule is available in the market various strength form like 10 mg, 25 mg,
50 mg,75 mg, 100 mg,150 mg.


Doxepin tablets are available in the market are mainly 3 mg and 6 mg.


Oral concentrate are available in market are 10 mg/ml.


For the depression, the dose is initiated form 25 mg and gradually increase the dose after 7
days.
The maximum dose is 300 mg per day is taken. The maximum single dose is 150 mg.
When a single dose is increased 150 mg then the dose is taken after 12 hours. Or  consult
the doctor or pharmacist for better advice.


Before taking this medicine read the leaflet or drug information.


Price of doxepin

Somaxon pharmaceutical manufacture Silenor Tablets 3mg and 6 mg, Price of the tablets
for 30 Tablets is $208 in the USA.


Intas pharmaceutical Ltd manufacture Doxin 75 mg Capsule, Price of the 10 no of Capsule
are 104 rupees in India.


Eris Lifesciences ltd manufacture Spectra 75 mg capsule, Price of 10 no of the capsule are
127 rupees in India.



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