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Amitriptyline Use, Side Effect, Mechanism of action and other Information

Amitriptyline Use

Amitriptyline is used for the treatment of depression, neuropathic pain in the adults, headache
due to chronic tension, migraine disease.
Amitriptyline tablets
Amitriptyline tablets

It is also used for the treatment of bed wetting in case of below age group 6 year. For this
condition, the only doctor can prescribe medicine or pharmacist.
Amitriptyline is also used for the treatment of anxiety and tension. And helps to give good
This medication helps to improve the mood and feeling happy. And helps to raise the
energy level in the body.
Sometimes a doctor prescribes this medicine to treat severe back pain and neuralgia.
This medicine is good for nerve pain when you take a lower dose.
6 condition when you don’t take Amitriptyline tablets
  • If patients are allergic to Amitriptyline.
  • If you have any heart problem, like heart attack, coronary heart block, disturbance in
heart rhythm.
  • If patient takes monoamine oxidase inhibitor.
  • If the patient takes MAOIs before 14 days.
  • If patients take moclobemide like medicine.
  • If patients have severe liver disease

Amitriptyline side effects

Like other medicine, this medication has some side effects. Most common side effects
are heart problem like prolong QT interval which is identified in the electrocardiogram.
Due to these effects may have
  1. Slow heart rate
  2. Heart failure to pump the blood, finally heart failure
  3. Potassium and magnesium level in the blood are may increase or descrese.
  4. You may suffer thyroid problems.
  5. Some patients have rare side effects like blurring vision, rainbow vision and eye pain.
  6. This condition may lead to acute glaucoma.

Some rare side effect are seen like

Constipation, swollen of the stomach, fiver, and vomiting.
Some time liver may affect leads to jaundice.
Bone marrow may affect sign and symptoms are Bruising, bleeding, pallor, the shore of
Sucidal thought may come.
Other side effects are
  • Drowsiness
  • The shakiness of hand or other body parts.
  • Dizziness
  • Headache
  • Irregular rapid heart bit
  • Low blood pressure when immediate stand up.
  • Dry mouth
  • Constipation
  • Nausea
  • Sweating
  • Weight gain
  • Confusion
  • Sexual disturbance
  • Change in taste
  • Dilated pupils
  • Urination disorder
  • Fatigue
  • Felling thrusty

Amitriptyline Mechanism of action

This medicine increases the tryptophan level in the body so PRL level in the body.
There are several mechanisms are helps to increase Tryptophan level
  • Increase tryptophan availability in the brain.
  • Incerase the synthesis of 5-HT Form tryptophan.
  • Incerase release of 5-HT form postsynaptic neuron.
  • Increase the blocking of 5-HT form presynaptic neuron.
  • Increase the sensitivity of postsynaptic neurone.
Amitriptyline structure
Amitriptyline structure

Amitriptyline helps to block reuptake neurotransmitter to presynaptic vesicle so chances
of binding of the neurotransmitter to postsynaptic vesicle are increasing.
Due to more binding of the neurotransmitter to postsynaptic vesicle neuronal signal is pass
more which cause less chance of depression.
According to one study, this medicine can decrease CSF 5-HT turnover in depressed
patients as decreased levels of the 5HT metabolite 5-Pharmacokinetics acid.
This medicine ability to enhance the PRL by stimulating effects of tryptophan due to the
increase of postsynaptic sensitivity.
Longterm treatment of this medicine may increase 5-HT postsynaptic receptor sensitivity
through compensatory changes in receptor function and prolonged postsynaptic receptor
Other similar medicine named Doxepin is working same mechanism of action.

Amitriptyline Pharmacokinetics

This medicine is well absorbed orally and well plasma binding capacity.
Volume of distribution is approximately 20 liters/kg. Metabolized in the liver by the enzyme
cytochrome P450. for example CYP2D6, CYP3A4, CYP1A2 etc.
This medicine is excreted through urine.T1/2 of this medicine is around 16-24 hours.
Due to more t1/2 One dose before going to sleep is working fine.

Amitriptyline Interaction with other medicine

This medicine increases the effect of sympathomimetic amines which is mainly used for
treated cold and asthma. One example is phenylephrine.
This medicine also decreases the effect of ephedrine and tyramine.
This medicine reduces the antihypertensive action of guathenedine and clonidine to stop
the entering into the neuron.
This medicine increase the action of alchol and antihistaminics.

Amitriptyline Dose

This medicine can take with food or without food. To avoiding any side effect you can take
this medicine before going to sleep.
For depression
You can start this medicine 25-50 mg. Gradually increase the upto 100-200 mg per day.
The maximum dose for depression is 300 mg per day.

For migraine lower dose work well. So 10-25 mg is working well for migraine pain.

For eating disorder

This medicine is helping increase appetite. So 150 mg of this medicine per week can help
to increase the taking food.

Amitriptyline Brands and Price

Linux laboratories ltd manufacture Triptaz 75 mg tablets in the price of 57 rupees for
10 tablets. Triptaz 25 mg tablets are also manufacture this company in the price 23 rupees.

Lundbeck India pvt ltd manufactures Sarotena 25 mg tablets of price 23 rupees in India.
Which is easily available in markets.

Over the world Amitriptyline price is 4-10 dollar.


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