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Fenofibrate Use , Side Effect, Mechanism of action and Dose

Fenofibrate Use, Side Effect and Mechanism of action

Fenofibrate is used for the treatment of heart attack and heart stoke . this medicine
mechanism is lowering the blood LDL (Low density lipoprotein ) and triglycerides.
Fenofibrate Capsule
Fenofibrate Capsule


This medicine is showing there action well when patients are controlling their food such as
low fat food or cholesterol free food.


Mainly it helps to increase the HDL level two way in the body
  • Primary Hypercholesterolemia and Mixed Dyslipidemia
  • Severe Hypertriglyceridemia

Primary Hypercholesterolemia and Mixed Dyslipidemia

Before I explain How Fenofibrate Increase the HDL level in the body I would like to
explain What is Hypercholesterolemia ? and what is Mixed Dyslipidemia?


Hypercholesterolemia is condition where the high levels of cholesterol in the blood and
high blood lipid that's reason Increase the fat deposition in the body . so due more fat
deposition finally Heart stoke , type 2 diabetes and thyroid like disease are attacks.


Dyslipidemia is also condition where triglyceride , cholesterol and phospholipid are
abnormally increased due to intake of highly fat containing food.


In the above both the cases Fenofibrate are working to reduce elevated LDL ,total
cholesterol, triglycerides and apolipoprotein B (Apo B) and simultaneously helps to increase
HDL cholesterol in the adults patients .

Severe Hypertriglyceridemia

This condition Triglyceride, Serum level are gradually increase to 2000 mg/dL. Which is
may produce pancreatitis and cardiovascular disease. Fenofibrate with proper diet can
helps to improving the glycemic control to the body.

Fenofibrate side effects

Like all the category of medicine this medicine have some side effect. Some people are
have show life threatened side effect and some are show common side effect .


Here we classify three different type
Common side effects
Infrequent side effect
Serious side effect

Common side effects

Nausea and vomiting                           stomach pain
Diarrhoea                                             flatulence
Headache                                            stuffy nose

Infrequent side effect

Rash                                                    Itching
Urticaria                                               gallstones
Inflammation of the pancreas              Deep vein thrombosis
Sensitivity to Light

Serious side effect

Hair loss                                              Muscle pain
Muscle weakness                                Muscle cramp
Muscle inflammation                            sexual life problem
Skin reaction to light                            Hepatitis


As per the laboratory test fenofibrate commonly change the live enzyme and kidney function.
Some time this medicine also change the hemoglobin and white blood cell in the blood.
If you are seen any side effects immediately inform the doctor or the pharmacist for the
safety purpose. Read the leaflet before taking the medication which gives more information
about the medicine.


Fenofibrate Mechanism of action

Fenofibrate are comes from the fibrate groups. Chemical name of Fenofibrate is 2-[4-❲4-chlorobenzoyl❳ phenoxy]-2-methyl-propanoic acid.


This medicine are helps to activate the enzyme Lipoprotein lipase. This enzyme key role is
degradation of VLDL (Very low density Lipoprotein). So the thyroglobulin level in the blood
are ultimately decrease.


This whole process are continued by Peroxisome proliferator activated receptor πžͺ (PPARπžͺ).
This receptor PPARπžͺ is located in the liver. Which is a gene transcription regulating receptor.


When this receptor activate it increase the synthesis of lipoprotein lipase and fatty acid
oxidation. This medicine also decrease the hepatic thyroglobulin synthesis.


This medicine are helps lower thyroglobulin levels 20-50% by the increase HDL channel
10-15% and decrease 10-15% of LDL channel.


Generally free fatty acid are break down by 𝛃-Oxidation pathway to give the energy to
the body.


Apo A1 and Apo AII protein are helps to increase the HDL levels in the blood.
Apo CIII synthesis are reduce the  π›ƒ-Oxidation process resulting increase the free fatty
acid in the body. Which is harmful to the human health.


Fenofibrate help to stimulate the Apo AI and Apo AII for the synthesis of the more
friendly HDL in the body simultaneously decrease the production of Apo CIII to protecting
the process of 𝛃-Oxidation pathway.


Overall process helps to controlling the LDL, free fatty acid and TG in the body.

Pharmacokinetics of Fenofibrate

Fenofibrate is a prodrug of fenofibric acid . In the body fenofibrate is converted into
fenofibric acid by ester hydrolysis to show the pharmacological action.

Absorption

This medicine is hydrophobic in nature so this medicine is not given through injectable form.
But it well absorbed by the gastrointestinal tract.


60% of the drug are eliminated by urine and 25% of this excreted by feces.
Plasma peak area occurred in the 6-8 hours after administration of the dose.
Absorption of this medicine is increase when this medicine is take along with food.


Fenofibric acid is metabolised by glucuronic acid conjugation not by cytochrome p450
enzyme.Same dose of this medicine works both the age group e.i younger patients and
older patients.

Dose

Before i explain about dose you must know that fenofibrate is very effective when it take
along with lipid lower diets or cholesterol free diets.


Excess body weight and excess intake of alcohol are importance factor of hypertriglyceridemia.
Before continue this medication try to doing exercise for better health life.
If you taking any kind of other medication which increase the lipid level in the body then
you must consult your doctor for better advices.

Dose for Primary Hypercholesterolemia and Mixed Dyslipidemia

For this condition Initial dose 160 mg per day

Dose for Severe hypertriglyceridemia

Initial dose for this condition is 54 to 160 mg per day. Maximum dose is 160 mg per day.


Some Warning

Those patients are suffer diabetes (specially older age group) or hyperthyroidism the risk of
skeletal muscle toxicity may appear.


There are various type of symptoms are shown like muscle tenderness or weakness ,
elevation of creatine phosphokinase levels ,muscle pain , malaise and fever shown.


When dose is increase 107 mg to 160 mg per day there are some adverse effect shown
in the liver function. Imidiate report side effects to doctor.

Brand name of Fenofibrate and price

There are other similar drug which is showing the similar effect are
  • Clofibrate
  • Gemfibrozil
  • Bezafibrate
Bellow mention some Brand name, manufacture by company and Price


Sr.No
Brand Name
Manufacture By
Price
1
Tricor
Abbot
160mg 33$ for 30 tablets
2
Triglide
SKYEPHARMA AG
160 mg 306$ for 30 tablets
3
Lofibra
Teva
67 mg 106$ for 100 tablets
4
Lipofen
Kowa Pharmaceuticals America
50 mg 349$ for 90 tablets
5
Fenoglide
Bausch Health Companies Inc.
120 mg 234$ for 30 tablets


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