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Tamsulosin use and side effect | Other information about Tamsulosin

Tamsulosin use and side effect

Tamsulosin is used for the treatment of the symptoms enlargement of prostate gland .other wise called benign prostatic hyperplasia (BPH). this medicine does not act directly on the prostate gland it relaxes the muscle of the urinary bladder. so the patient feel the relax during urination. And it also helps to cure the symptoms like Frequent Urination, frequent Urge to urinate, Weak or interrupted urine symptoms and straining to urinate.
Tamsulosin capsule
Tamsulosin capsule

One question must come to your mind What is the prostate ?
The prostate is the gland that helps to ejaculation of siemens. actually it does not produce the semen it only regulates the ejacuation of semen through urethra . due to some unknown reason this
gland enlarges as the urethral tube are passing through prostate .urethral tube blocks.
which is ultimately block the urination.

Side effect  

Like other medicine this show some common side effect in some patient but not all the
  • Dizziness
  • Ejacuation disordor 
  • Retrograde ejacuation (semen does not comes out it goes to the urinary bladder)
  • Ejacuation failure
  • Some uncommon side effect are seen in the taking of this medication like
  • Headache
  • Heart rate more as compared to normal heart rate
  • Reduce blood pressure 
  • Rhinitis
  • Diarrhea
  • Feeling sick
  • Vomiting 
  • Constipation
  • Weakness
  • Rash
  • Etching 

Mechanism of action

Tamsulosin is blocked the alpha receptor which is located in the blood vessel and urinary
bladder . This medicine is block the alpha 1 receptor by selectively anatoginst.
Alpha 1 receptor is present in the postsynaptic vesicle or organo receptor .when
neurotransmitter are release and comes to bind with alpha 1 receptor show the constriction
of muscle . there are two subtype of alpha 1A and alpha 1B receptor.
Alpha 1B receptor are present in the Blood Vessel to constrict the blood vessel and increase
the blood pressure . Alpha 1A receptor are present in the urinary bladder and constriction
occur .so the patient are suffer the pain during the urination or infrequent urination occur.
Tamsulosin selectively bind with the alpha 1A receptor and relax the muscle and urine flow
easily. This medicine is coming under the alpha-adrenergic agonist but not use in the
treatment of blood pressure because it is the selective antagonist.

How tamsulosin metabolize

Tamsulosin is metabolized by cytochrome P450 enzyme in the liver. About 10 % of the
medicine is excreted through urine in the unchanged form. It metabolism helps cytochrome
isoenzyme CYP3A4 and CYP3D6 .this medicine is come with the glucuronide conjugation
and sulfate conjugation to show the effect. It also inhibit hepatic drug metabolism to
show the effect of the drug. this medicine bound with the plasma protein 94- 99% mainly
alpha1 acid glycoprotein .it absorption through the oral administration is well in the fasting
condition Tmax is 4-5 hour if take without food and 6-7 hour with food.

Tamsulosin Dose

Tamsulosin is available in the salt form like tamsulosin hydrochloride and it is very potent
drug small dose show it actions more effectively. This medicine mainly comes to the market
capsule form as 0.2 mg , 0.4 mg and 0.8 mg .
5-Hydroxytryptamine is also given with a combination of this medicine for a better result.
Dose for Benign Prostatic Hyperplasia
Initial dose for the disease 0.4 mg oral dose take per day .The maximum dose for this disease
you can take 0.8 mg oral dose per day. before taking this medication consult with your
doctor or pharmacist . if you have any side effect or allergic reaction to this medication told
your doctor to avoiding risk of side effect.if you discontinue the medication disease may grow
again .

There are no renal dose adjustment. If the patient having no effect in the 0.4 mg dose , dose
amount is increase to 0.8 mg per day. Don’t crush the capsule before taking it may increase
the effect of the drug.Best time to taking this medication is night time .
This medicine is very helps the patient who have postural hypertension by taking ‘zosin’
group medicine like terazosin or prazosin.

Drug Interaction

This medicine is show drug interaction when combining with other medicine . so beware
before taking this medication. Some time doctor don’t concentrate about this and prescribe
along with other medication which show the interaction.

You must avoid tamsulosin if you taking this medication

HIV /AIDS treatment with nevirapine or ritonavir
Treated for fungal infection with medicine like Itraconazole, ketoconazole, posaconazole
Using antibiotics like chloramphenicol, clarithromycin
Boceprevir, telaprevir
Cancer medication with imatinib
Alpha-blocker like terazosin, prazosin
Treatment of depression with selective reuptake inhibitors like sertraline or fluoxetine

Some brand name  

Tamsulosin was first marketed as brand name this medicine is coming to
market by various companies. TAMLOCEPT 0.4 mg capsule by lupin ltd. DYNAPRES 0.4 mg
Capsule by Dr Reddy’s Laboratories Ltd.VELTAM 0.4 mg Tablets by intas pharmaceutical ltd.
FLODART tablets 0.4 mg by aristo pharmaceutical ltd .

Price of tablets

this medicine price is strats form 5- 8.52 rupees per tablets/capsule in india .
For the U.S price of tablets /capsule is around 13 dollar for 90’s unit .


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