Sumatriptan side effect and mechanism of action


What sumatriptan used for

Sumatriptan is used for the treatment of migraine headache and it also used for the
treatment of other migraine symptoms like vomiting , pain and eye irritation or light sensitive .
this medicine is use for  when migraine attack. this medicine is not used for the long term
use. It is only relief the pain in migraine attack it has no ability to stop the migraine attack
Sumatriptan tablets use for the migraine headache
Sumatriptan tablets 


Before taking this medication patient must know about sumatriptan form the leaflet or form
the doctor or the pharmacist.
Doctor Prescribe the sumatriptan medicine when doctor properly diagnosis or doing some
test please don’t give the medicine to other even if they have same symptoms or effect
produce .

Some condition when you don’t take this medicine


  • If you  if you have some allergic reaction to  this medicine then you must avoid this
medicine
  • if you have Heart problem such as angina pectoris, ischaemic heart disease Or heart attack.
  • If you have pain in the leg such as muscle cramp.
  • If you have high blood pressure then don't take this medicine.
  • if the patient is suffering any kind of liver disease.
  • If the patient is taken any other type of migraine headache medicine.
  • If the patient is taking monoamine oxidase  inhibitor Or any other kind of antidepressant.

What is side effect of sumatriptan

There are  more common side effect like  Allergy, rash,hives, wheezing ,swollen eyelids,
face or lips.
Some patient are may affect the heaviness, pressure , tightness or pain in the chest throat
and other part of the body, feeling of unusual sensation numbness, tingling and warmth,
Some other side effect are Feeling sick, being sick (nausea and vomiting) tiredness,
Drowsiness, dizziness,feeling weak,getting hot flashes,increase blood pressure,shortness
of breath,aching muscles.
Some patients liver function may changes.

Sumatriptan mechanism of action

Sumatriptan is comes under serotonin and also structurally looks like serotonin (5HT).
This medicine is particularly acts on the 5HT 1D and 5HT 1B . which is responsible for the
vasodilation of blood vessel. This medicine having particular action . in the migraine
headache blood vessel in the brain are dilation due to some unknown reason .so dilation
of the blood vessel flow of blood reduced .
Sumatriptan  chemical structure
Sumatriptan structure 

It inhibit the release of calcitonin gene related peptide by binding with the receptor 5HT 1D
and it bind with 5HT1B show the vasoconstriction in the cerebral arteries.


Sumatriptan does not pass the blood brain barrier so the injection form is more active
when the patient is injected through subcutaneous rout. Oral bioavailability is very less(16%)
after 2 hour its bioavailability is 64% if the patient take 100 mg tablets . if the patient take
6 mg injection bioavailability is 96% and after 2 hour it is 50 %.

Avoid some type of food in migraine    

If the patients suffer the migraine attacks then they must avoiding such type of food given
below
Chocolate , nuts, cheese, wine , junk food (brugger ,piza)
Patient are avoid to travel ,sleep well and trying to avoid the stress.

Dose of sumatriptan

Sumatriptan is available in the tablet and also in the injectable form . Sumatriptan tablets
are avilable in 50 mg and 100 mg .

For the adults

For the migraine attacks recommended dose is 50 mg of sumatriptan but some patients
are taken 100 mg tablets .
Children are avoiding to take the sumatriptan tablets for the treatment of migraine attacks.
Above the 65 year age group patient this medicine are not recommended.

Administration

Sumatriptan is taken by the help of water .there are no time to take this medicine .
when migraine attacks are you can take this medicine for the instance action of the
sumatriptan.Don’t crush the tablets or chew the tablets when taken through orally .
If the symptoms are not gone in the first dose then you don’t take the second dose for the
same attacks . but you can take the next dose for the conjugative attacks. You can take
300 mg of sumatriptan in between 24 hours .

Metabolism of sumatriptan

Sumatriptan is metabolism by the monoamine oxidase A to form the
2‐{5‐[(methylsulfamoyl)methyl]‐indole‐3‐yl}acetic acid then it is bind with glucuronic acid .
it is easily excreted through the bile and urine about 3 % of this medicine are excreted as
unchanged form.

Interaction with other medicine

Sumatriptan is show the drug interaction with same kind of the drug which is helps to
treatment of migraine attacks ,like ergotamine .


This medicine is interact with SSRIs (selective serotonin reuptake inhibitor ) or SNRIS
(serotonin noradrenaline reuptake inhibitor )  use for treatment of depression, are showing
serotonin syndrome like sweating ,dehydration, hallucination, muscle spasm, increase the
heart bit.
Some other medicine are interaction with sumatriptan are

  • Citalopam
  • Duloxetine
  • Fluvoxamine
  • Paroxetine
  • Sertraline
  • Voriconazole
  • Venlafaxine


If the patient are treatment depression with monoamine oxidase inhibitor then they are not
take the medicine .

Some brand name and price of the Sumatriptan

Sumatriptan is available in the market as brand medicine and non brand medicine , some
brand medicine are imitrex, imigran, sumatran ,sumatriptanum, sumax .
Sun pharmacetical manufacture as a name SUMINAT 25 mg tablet price 33.83 rupees per
unit. And SUMITREX 100 mg tablets are also manufacture by SUN Pharmacutical price 74
rupees in India.
Intas pharmaceutical manufacturing the combination medicine name sunapro tablets
containing sumatriptin 85 mg +naproxen 500 mg as the price 72 rupees per unit .






Sumatriptan side effect and mechanism of action Sumatriptan side effect and mechanism of action Reviewed by aboutmedicine on 21:36 Rating: 5

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