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Risperidone side effect, mechanism of action,use


Risperidone side effect, mechanism of action, use

What is Risperidone?

Risperidone is medicine use as antipsychotic treatment. Antipsychotic diseases like

How to take risperidone

Before taking of this drug must read the manual or leaflet which is present along with this medicine. if you are not comforted with this then take the advice of doctor or pharmacist.
It is also used for the treating of obsessive-compulsive disorder .in this disease patient are doing the one work repetitively. It also helpful for dementia. But FDA does not approve for the treatment of dementia.
Risperidone tablets

The doctor always prescribe the drug for beater effect of in the patient or cure the patient if you have side effect occurs or any discomfort with this drug contact with your doctor immediately.

RISPERIDONE SIDE EFFECT

Mainly common side effect are shown movement problem, sleepiness, seeing a problem, constipation, increased weight .serious side effect permanently movement problem otherwise known as tardive dyskinesia, neuroleptic malignant syndrome, increase risk of sucide , increase the blood sugar level. It not known to take safe of pregnancy discuss with your doctor or don’t take in the pregnancy.in this medication increase the risk of heart attack.
Drug interaction
Risperidone plasma levels reduce when patient take along with the Carbamazepine and enzyme inducers like barbiturate or phenytoin .dose of risperidone increase if the patient take both the medicine along with risperidone.
If the patient take selective serotonin reuptake inhibitor like fluoxetine it increases the plasma level of Risperidone. Risperidone is cause of hypotension.

 
Risperidone chemical structure
Risperidone structure
Risperidone mechanism of action

Risperidone is act on D1 and D2 receptor antagonist which is dopamine receptor.
Dopamine receptor are D1 ,D2, D3,D4,D5. Also it an antagonist of receptor 5HT2A, Histamine receptor (H1) , adrenergic receptor (alpha 1).
Dopamine has 4 pathway such as
MESOLIMBIC PATHWAY
This pathway mediate the positive action of psychosis. Example hallucination.
MESOCORTICAL PATHWAY
Underactive in schizophrenia and mediate psychosis.
NIGROSTRIATAL PATHWAYS
It mainly occur due to deficiency of dopamine that is reason of camping occur and slow the movement and other activity.
TUBEROINFUNDIBULAR PATHWAY
It mainly prolactin secretion. That causes sexual control.
Risperidone has blocked the dopamine receptor in the mesolimbic pathway and it mediates the antipsychotic efficacy.it decreases the positive symptoms.
Risperidone brand name
Some brand name are Risperdal, Risperdal consta, Risperdal M-Tab , Risperdal Quicklets and Risperlet.

Risperidone History

In the 1980s first study has started and in 1993s united state get the approval for sell the medicine in the market. World health the organization listed the medicine for essential medicine and most effective drug.

Risperidone Price

In India Risperdal are mainly two strength 1 mg ,2 mg and 4 mg
Risperdal 2 mg price 155 rupees for 30 tablets and Risperdal 4 mg tablets price is 304 rupees for 30 tablets which is manufacture by  Johnson & Johnson Pvt. Ltd. Risperdal 1mg tablets price is 93.60 rupees for30 tablets.





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