Risperidone side effect, mechanism of action, use
What is Risperidone?
How to take risperidone
Before taking of this drug must read the manual or leaflet which is present along with this medicine. if you are not comforted with this then take the advice of doctor or pharmacist.
It is also used for the treating of obsessive-compulsive disorder .in this disease patient are doing the one work repetitively. It also helpful for dementia. But FDA does not approve for the treatment of dementia.
The doctor always prescribe the drug for beater effect of in the patient or cure the patient if you have side effect occurs or any discomfort with this drug contact with your doctor immediately.
RISPERIDONE SIDE EFFECT
Mainly common side effect are shown movement problem, sleepiness, seeing a problem, constipation, increased weight .serious side effect permanently movement problem otherwise known as tardive dyskinesia, neuroleptic malignant syndrome, increase risk of sucide , increase the blood sugar level. It not known to take safe of pregnancy discuss with your doctor or don’t take in the pregnancy.in this medication increase the risk of heart attack.
Risperidone plasma levels reduce when patient take along with the Carbamazepine and enzyme inducers like barbiturate or phenytoin .dose of risperidone increase if the patient take both the medicine along with risperidone.
If the patient take selective serotonin reuptake inhibitor like fluoxetine it increases the plasma level of Risperidone. Risperidone is cause of hypotension.
Risperidone mechanism of action
Risperidone is act on D1 and D2 receptor antagonist which is dopamine receptor.
Dopamine receptor are D1 ,D2, D3,D4,D5. Also it an antagonist of receptor 5HT2A, Histamine receptor (H1) , adrenergic receptor (alpha 1).
Dopamine has 4 pathway such as
This pathway mediate the positive action of psychosis. Example hallucination.
Underactive in schizophrenia and mediate psychosis.
It mainly occur due to deficiency of dopamine that is reason of camping occur and slow the movement and other activity.
It mainly prolactin secretion. That causes sexual control.
Risperidone has blocked the dopamine receptor in the mesolimbic pathway and it mediates the antipsychotic efficacy.it decreases the positive symptoms.
Risperidone brand name
Some brand name are Risperdal, Risperdal consta, Risperdal M-Tab , Risperdal Quicklets and Risperlet.
In the 1980s first study has started and in 1993s united state get the approval for sell the medicine in the market. World health the organization listed the medicine for essential medicine and most effective drug.
In India Risperdal are mainly two strength 1 mg ,2 mg and 4 mg
Risperdal 2 mg price 155 rupees for 30 tablets and Risperdal 4 mg tablets price is 304 rupees for 30 tablets which is manufacture by Johnson & Johnson Pvt. Ltd. Risperdal 1mg tablets price is 93.60 rupees for30 tablets.