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Ranitidine :Use ,side effect, Dosage, action, Price,History of ranitidine

Ranitidine :Use ,side effect, Dosage, action, Price

Use of Ranitidine

Ranitidine is maily use in high Acidity, Ulcer tritment.
Ranitidine is use in conditions in which it is profitable to suppress gastric acid secretion .
Use in appropriate doses ,all available agents have similar efficacy. However, proton
Pump inhibitors ,because of higher efficacy and equally good tolerability, have outstripped H2 blockers.
Ranitidine produce rapid and marked pain relief with in 2 to 3 days, 60-85 % ulcers heal at 4 weeks and 70-95 % ulcers heal at 8 weeks.
Ranitidine tablets
Ranitidine tablets

Dose of ranitidine

Ranitidine are avalable in the market as solid dose and parenteral dose
For ulcer healing 300 mg at bed time or 150 mg in bed time for maintenance 150 mg at bed time .or injection of 50 mg in intra muscle or slow intra venous injection every 6-8 hour .
Rapid intra venous injection cause hypertension .
Some brand name which contation only ranitidine like
RANTAC 150 mg ,300 mg tabs ,50 mg /2 ml inj.

Advantage of Ranitidine

Before told about ranitidine advantage know about cimetidine
Cimetidine is also work as like of ranitidine .cimetidine is come to market first as compare to ranitidine .
Ranitidine is a nonimidazole  has a furan ring H2 blocker
Ranitidine is 5 time more potent than cemitidine and its half life is same as ranitidine (2-3 hour) longer duration of action like 24 hour due high potent drug.
No antiandrogenic action ,does not increase prolactin secretion or spare estradiol form hepatic metabolism ---no  effect on male sexual function or gynaecomastia.

Lesser permeability into the brain: lower propensity to cause CNS effects. In fact, little
effect outside g.i.t. has been observed.
 Does not significantly inhibit hepatic metabolism of other drugs; drug interactions mostly
have no clinical relevance.
Overall incidence of side effects is lower:headache, diarrhoea/constipation, dizziness
have an incidence similar to placebo.
 Ranitidine is mainly given all the patient Gastric ulcer creation due to stress
And drugs like NSAIDs,cholinergic ,histaminergic .
Ranitidine do not directly lower the acidity of stomach.
Ranitidine is widely use in India as well as other country

Side effect of Ranitidine

If ranitidine is given by injection then this type of side effect may occours Headaches and pain, burning.
Serious side effect may occour  like liver problems,slow heart rate ,pneumonia and potential of masking stomach cancer.there are the risk of clostridium difficilie colitis .
Advantage of ranitidine is it safe drug in pregnancy.

Histroy of Ranitidine

Ranitidine was discovered in 1976 and come into commercial use in 1981.
World health organization’s add in list of essential medicines ,ranitidine is the most effective and safe drug .1st it is available as ageneric mecdicine .
In the 2015 Price is about 0.01 to 0.05 USD PER tablets.
In the United states ranitidine is about 0.05 USD.
Ranitidine was first prepare as AH19065 BY John Bradshaw in the summer of 1977 in the Ware research laboratories of part of glaxo organization.

Adverse effect of Ranitidine

During clinical trail various type of adverse effect is occour
Central Nervous system ,cardiovascular system ,gastrointestinal ,liver, lungs, bloods .

Price of Ranitidine

If we tell about ranitidine then its other name is zantac
In the 2015 Price is about 0.01 to 0.05 USD PER tablets.
In the United states ranitidine is about 0.05 USD.
Zantac 150 mg price is 26 dollar for 65 tablets.


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