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Montelukast :Use,side effect ,dosage,action,Price


Use of Montelukast

Montelukast is mainly used for treatment of asthma ,exercise-induced bronchospasm
Allergic Rhinitis,(it is also known as hay fever, is the type of inflammation in the nose which
Is the overreact to allergins.

Asthma is a condition cause by inflammation in the airways. Though it may not a serious problem for some, it can be lethal to others, and the inflammation involved brings many discomforts to all who experience it. The muscles in the airways get irritated and begin to constrict. Airways will be then become more and more narrow resulting in difficulty passing airflow in and out of the lungs. Symptoms of asthma such as wheezing, chest tightness, and shortness of breath will soon follow. In addition, the inflammation causes the lining of the airways to produce more mucus which then leads to coughing.

 Montelukast is come under the leukotriene antagonist.in this category one another drug is Zafirlukast has the same action.
Montelukast tablets
montelukast tablets

Asthma symptoms may come from time to time depending on the daily activities of the person experiencing it. Some people can trigger an asthma attack through exercise, fumes, or pollen. These things cause the body of the asthmatic person to produce a chemical substance called leukotrienes. Leukotrienes are the main reason for the inflammation of the airways. Montelukast 10 mg is a great medication that helps control the symptoms of asthma.What is Montelukast?

Montelukast is a leukotrienes receptor antagonist that helps get rid of asthma symptoms. It is available in different dosages but among the most common is montelukast 10 mg. It also comes in different brand names like Singulair. However, montelukast generic forms are also available. Customers have the freedom to choose between the branded montelukast 10 mg and the generic. But just a little information from the makers of montelukast … it usually works after 3-14 days after the start of medication therapy, and therefore it is not used as a treatment for an acute asthmatic attack.

Side effect of Montelukast and zafirlukast

These two drug are very safe drug having very less side effect like
Headache and rashes.
Suicidal thought or action
Hallucination
Sleeping trouble
Tremor
restlessness
Eosinophilia and neuropathy are infrequent.
Some case of church Strauss syndrome has been reported.
Montelukast and zafirlukast are well absorbed orally ,highly plasma protein-bound and metabolized by CYP2C9, CYP2C8 and CYP3A4.
The plasma half-life of montelukast is 3-6 hours , zafirlukast  is 8-12 hour.
Some brand name of montelukast is EMLUKAST,MONTAIR,VENTAIR 4 mg ,5 mg,,10 mg tablets,ZUVAIR  10 mg ,20 mg tablets.

Action of montelukast

Asthma is mainly occour in morning and evening. Asthma and chronical obstruct pulmonary diseases are mainly same but asthma has main three Problem is also called triangle problem of asthma.
1 airway obstruction
2 smooth muscle hyperplasia
3 inflammation
Asthma has two action immediate action and late phase action
Type of asthma is two type
1 Atopic /Extrinsic
2 Non atopic /Intrensic
Non atopic is case which is cause by aspirin, Exercise, stress, cold, occupational toxic

Bronchial asthma is occours due to cystenyl leukotrienes(LT-C4/D4) for that reason leukotriene antagonists are develop.

CysLT1 receptor is responsible for  broncho constriction , increased vascular permeability and recruitment of eosinophil .
Bronchodilation ,reduced sputum eosinophils count ,suppression of bronchial inflammation and hyperreacctivity are noted in asthama patients.
Some studies have found that certain patients are responders while other s are nonresponders to anti-LT therapy.


Drug interaction of Montelukast

This drug has very few drug drug reaction.

So doctor prescribe the combination of motelukast  with a CYP2C8 substrate like
Amodiaquine or antimalarial drug could increase the  plasma concentration of the substrate .
Dosage of montelukast
What is montelukast ?
Montelukast is medicine which is available in the market as tablet, chewable tablets, granules, liquid .
Montelukast brand name of the tablets is singulair which is prepare by merck & co.
This medicine is not stable as its own molecule so it made as salt form.
Doctor mainly given the montelukast with adding some other drug.
Levocetirizine is mainly added with montelukast.

History of Montelukast

There is no information about the history of montelukast.

Dosage of montelukast

Montelukast is available in generic form and brand form.
Oral tablets are made 10 mg and chewable tablets are made 4 mg and 5 mg of strength.
For asthma treatment
Of above the age 15 year 10 mg once daily in the evening.

For age 2-5 year 4 mg chewable tablet once daily in the evening.
Pataint which is suffer exercise-induced bronchoconstriction they are taking the montelukast before 2 hour of exercise.
Montelukast is used only once per day if suffer multiple.
Donot stop the taking of the drug suddenly. if you suffer asthma.
Take the dose timely and the daily basis for proper working of drug.
If you take more drug it may cause overdose some symptoms are

  • pain in your abdomen
  • vomiting
  • trouble sleeping
  • thirst
  • headache
  • hyperactive behavior
Storage condition of montelukast is Room temperature.
The recommended dosage is one pill once a day daily for adults using montelukast 10 mg. Children, on the other hand, are not advised to take montelukast 10 mg tablets because the dosage is too high for them. Instead, they use lower doses like a 4-5 mg tablet each day.
However, given the fact that not all medications are suitable for everyone – especially if they are having special health conditions – taking montelukast 10 mg should only be done after consulting with your doctor first in order for serious health complications to be avoided. Don’t forget to tell your doctor if you have one of the following conditions:
• Pregnant or trying to become pregnant
• Breastfeeding
• Using other medications such as herbal or complementary medications
• If you have an allergic reaction to any of the ingredients found in montelukast 10 mg.
 






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