Ibuprofen : use, side effect, mechanism of action , Dosage, Price , Brand of ibuprofen

Ibuprofen : use, side effect, mechanism of action , Dosage, Price , Brand of ibuprofen

What is Ibuprofen ?

Ibuprofen is comes under Nonsteroidal anti-inflammatory drugs .(NSAIDS)
It have analgesic , antipyretic action . Ibuprofen is a propionic acid derivative.
Ibuprofen Use

Ibuprofen is widely use for

      Rheumatoid arthritis
      Osteoarthritis
       Any other musculoskeletal disorders
       Pain in the body
       Soft tissue injuries
       Fractures
       Vasectomy
       Tooth extraction
       Postpartum
        Suppress swelling and inflammation
       Headache
        Menstrual cramps
        Fever
        Pain due to common cold or flu
  Please don’t take the drug directly form the market ask the doctor or pharmacist.
There are many company are manufacturing this drug with combining other drug have its effect is different .
Ibuprofen is “OVER THE COUNTER” drug.(OTC)
Ibuprofen tablet use for anti inflamatory
Ibuprofen tablet


How to take Ibuprofen

Before taking this drug read the manual or leaf let present in side the box.
You can take this drug with food ,milk , an antacid or water.
 If your stomach disturbance , Don’t sleep after taking this drug for 10 minutes.

Ibuprofen Side effect

As compare to other drug side effect of ibuprofen are very less ,mild and their incidence is lower .
Side effect like
      Gastric discomfort
       Nausea
       Vomiting
       Gastric erosion

            Gastric erosion is known due to internal part of cell or tissue are damage.

       Natural blood loss
       Headache
       Dizziness
       Blurring of vision

            Blurring vision is other wise known as short site ness.

       Tinnitus

                Other wise known as ringing in the ears .many people are having same effect.
       Depression
       Rashes
        Itching
        Other hypertensive activity are observe

 Some major side effect

Those people are take ibuprofen for the long time they have the chances  of heart attack or heart stoke . if you had recent heart attack don’t take ibuprofen. Discuss with your doctor. if any one take ibuprofen and he/she has the symptom like chest pain, shortness of breath , weekness of one part of your body then immediate take to him medical.
If you have coronary artery bypass surgery is done then don’t take this medicine like ibuprofen.
Mechanism of action of Ibuprofen

Ibuprofen is propionic acid derivatives.
It directly act on cox 1 and cox2 selative enzyme and stop the pain mechanism.

How pain ,inflammation are occour

There are no store of prostaglandin in the body they are directly synthesized form membrane lipids when get some external/appropriate stimuli.
Stimuli activate hydrolases ,also stimulate phospholipase A .probably intracellular ca+ increase.
Then cyclooxygenase pathway starts.
Phospholipase A is responsible for arachidonic acid synthesis .
Arachidonic acid is cyclooxygenase and produce PGG2  and PGH2 .
Cyclooxygenase are two type enzyme COX1 and COX 2.
PGH2 is isomerases and produce PGE2 ,PGD2, PGF2 .These three are mainly responsible for pain ,fever and inflammation .
PGH2 is then converted into TXA2 by the procress thromboxane synthase .TXA2 is not stable in this state for long time it is converted into TXB2 suddenly.
it also converted into platelet.
PGH2 is also converted into PGI2 by the procress prostacyclin synthase.PGI2 is not stable it is converted into 6 keto-PGF1.
This PGD2 ,PGE2, PGF2 are activate the neuron which act on the brain for sensetion of pain ,inflammatory, fever.

How ibuprofen act on body

Ibuprofen directly bind with COX1 and COX2 enzyme and stop all the step of synthesis of PGD2 ,PGE2 and PGF2 .So no inflammation ,pain and fever are occour.
Ibuprofen plasma half life is 2 hour.
Ibuprofen structure ,chemical structure
Ibuprofen structure


Ibuprofen dosage

Ibuprofen are manufacture by various pharmaceutical company .
Ibuprofen are manufacture tablet and capsule of dosage 200 mg, 400 mg , 800 mg.
Generally doctor are prescribe 400 mg to 800 mg for adult dose for every 4 hours to 6 hours.
Don’t take more ibuprofen like 2400 mg in a day it causes adverse drug reaction.

Ibuprofen iv dose for pain

Ibuprofen is given to cure the pain symptom 400 mg to 800 mg every 6 hours. Maximum dose is not exceeds 3200 mg per day.

Ibuprofen oral dose

Ibuprofen is given to the orally 200 to 400 mg every 4 hours to 6 hours.

Ibuprofen brands

Ibuprofen have more brand name but I give some example
 Combiflam                                  Ibutabs
 Calsolor                                       Ibux
 Cap-profen                                     Ipren
 Brufen                                         irfen
Bufen
A-G profen
Alges-X
Ibuprox

Ibuprofen Price

Ibuprofen 200 mg price start in India form RS 3.00 to RS 10.00 for 10 tablets.
Ibuprofen tablet 400 mg tablets price starts form RS 11.00 for 15 tablets.
Brufen-400 mg tablets 15s manufacture by abbott india price is 10.92 rupees.
Ibugesic -400 mg tablets manufacture by cipla india price 11.33 rupess.
Ibuprofen 600 mg tablets in USA $ 0.11- $0.39 .
       
Ibuprofen : use, side effect, mechanism of action , Dosage, Price , Brand of ibuprofen Ibuprofen : use, side effect, mechanism of action , Dosage, Price , Brand of ibuprofen Reviewed by aboutmedicine on 21:46 Rating: 5

No comments:

Powered by Blogger.