Donepezil use, side effect, mechanism of action,Price

Donepezil use, side effect, mechanism of action,Price

What is donepezil ?

Donepezil is medicine comes to market name as Aricept treatment of Alzheimer’s disease .and it also use for the treatment of dementia and confusion. Donepezil also increase the  brain memory and intelligence and function of the mainly balancing and restoring the neurotransmitter in the brain.
Don’t take the medicine unnecessary for any other reason .read the manual or leaflet for take this medicine or consult with the doctor or pharmacist.

Donepezil tablets use for treatment alzheimer;s disease
Donepezil tablets

Side effect Donepezil

Donepezil having some common side effect like Diarrhea ,headache, insomania, nausea , vomiting .
Some case having chronic Abdominal pain, lack of appetite , yellowed skin , dizziness, slow heartbeat, sudden or substantial weight loss, weakness.

Mechnism of action

Mechnism of donoprezil actually not know clearly.but it may act as anticholinesterase .
Donepezil is bind with cholinesterase reversibly.and incease the acetylcholine.
Acetylcholine is very help full to our body mainly to the brain .it help to send the signal form one cell to another cell that’s the reason our brain working, .if neurotransmitter(acetylcholine) are not working perperly then body becomes paralyses .
Donepezil is acting on the anticholinesterase to prevent the breakdown of acetylcholine to choline and acetic acid so acetylcholine send the message to another neurotransmitter efficiently. Donepezil is a lipophilic drug it cross the blood brain barrio and it act on the CNS more effectively .Donepezil is bind with cholinesterase binding site as competitively with acetylcholine 
Donepezil enantiomer structure
Donepezil structure

Donepezil metabolism

Donepezil is metabolized by the enzyme Cytochrome Isoenzyme name 2D6 and 3A4.Rate of metabolism of donepezil is slow. Donepezil takes 3 to 4 hours to obtain the maximum plasma concentration. Oral dose of donepezil produce high plasma concentration also depend on the dosage of medicine.if the patients are takeing the small dose frequently half life of the donepezil is aporx. 70 hours. Donepezil hydrochloride bound aprox. 96 % with plasma proteins.28 % aprox unrecover form the body.Donepezil is mainly excreated through the urine.
Donepezil is study as radioactivity lable C14. Sex ,smoking history and race have no clinically any affect to plasma concentration of donepezil.

Donepezil Dosage

Donepezil is available in the market 5 mg ,10 mg , 20 mg
Mainly donepezil is given to patient first 5 mg then gradually increase the dose per day. zonepezil taking  best time is evening and morning.
To coure the patient for intermediate state of Alzheimer disease dose is given by the doctor 10 mg orally per day upto 4 to 6 weeks after completion of initial dosage .
When patient are suffer sever Alzheimer’s disease dosage is given to the patient 20 mg per day for 3 months. 5 mg dose of donepezil is less incidence than 10 mg dosage of donepezil. But adverse effect of donepezil is similar with 5 mg and 10 mg .

Donepezil taking precaution

Patient must take some care which is affect the heart disease , cardiac conduction (some muscle in heart cell are sending the signal to contract the heart), chronic obstructive pulmonary disease, asthma , severe cardiac arrhythmias and sick sinus syndrome(sinus dysfunction)
If any portion is taking NSAIDS or patient suffer the peptic ulcer disease high risk of gastrointestinal bleeding occours.slow the heart beat also seen in the patient .this type of symptomps are more when dose of donepezil is increase 5 mg to 10 mg.

Donepezil price

Eisai pharmaceutical manufacture the Donepezil as mane of ARICEP SR 23 mg 10 Tablets price 350 rupees .
Sun pharmaceutical ltd manufacture the donepezil as name of Donetaz sr 23 mg for 10 tablets price is 250 rupees.
Cipla manufactrure the donepezil as name of DONECEPT 5 mg and 10 mg according to the dose for 10 tablets 108.65 rupees and 150.65 rupees .

Reference: all the information are collected form wikipedia

Donepezil use, side effect, mechanism of action,Price Donepezil use, side effect, mechanism of action,Price Reviewed by aboutmedicine on 22:29 Rating: 5

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