Skip to main content

Donepezil use, side effect, mechanism of action,Price

Donepezil use, side effect, mechanism of action, Price

What is donepezil?

Donepezil is the medicine that comes to the market name as Aricept treatment of Alzheimer’s disease .and it also uses for the treatment of dementia and confusion. Donepezil also increases the brain memory and intelligence and function of the mainly balancing and restoring the neurotransmitter in the brain.
Don’t take the medicine unnecessary for any other reason .read the manual or leaflet for taking this medicine or consult with the doctor or pharmacist.

Donepezil tablets
Donepezil tablets

Side effect Donepezil

Donepezil having some common side effect like Diarrhea , headache, insomnia, nausea, vomiting.
Some case having chronic Abdominal pain, lack of appetite , yellowed skin, dizziness, slow heartbeat, sudden or substantial weight loss, weakness.

Mechanism Action of Donepezil

Mechanism of donepezil actually not know clearly. but it may act as an anticholinesterase .
Donepezil is bind with cholinesterase reversibly.and increase acetylcholine.
Acetylcholine is very helped full to our body mainly to the brain .it helps to send the signal form one cell to another cell that’s the reason our brain working, .if neurotransmitter(acetylcholine) are not working properly then the body becomes paralyzes.
Donepezil is acting on the anticholinesterase to prevent the breakdown of acetylcholine to choline and acetic acid so acetylcholine sends the message to another neurotransmitter efficiently. Donepezil is a lipophilic drug it crosses the blood-brain barrio and it acts on the CNS more effectively .Donepezil is bind with cholinesterase binding site as competitively with acetylcholine 

Donepezil metabolism

Donepezil is metabolized by the enzyme Cytochrome Isoenzyme name 2D6 and 3A4.The rate of metabolism of donepezil is slow. Donepezil takes 3 to 4 hours to obtain the maximum plasma concentration. An oral dose of donepezil produces high plasma concentration also depends on the dosage of medicine.if the patients are taking the small dose frequently half-life of the donepezil is approx. 70 hours. Donepezil hydrochloride bound with plasma proteins aprox. 96 % and rest of all 28 % remove unchanged or uncover form the body. Donepezil is mainly excreated through the urine.
Donepezil is studied as radioactivity lable C14. Sex , smoking history and race have no clinically any effect to plasma the concentration of donepezil.

Donepezil Dosage

Donepezil is available in the market 5 mg, 10 mg, 20 mg
Mainly donepezil is given to the patient first 5 mg then gradually increases the dose per day. donepezil taking the best time is evening and morning.
To cure the patient for an intermediate state of Alzheimer disease the dose is given by the doctor 10 mg orally per day up to 4 to 6 weeks after completion of the initial dosage.
When a patient suffers severe Alzheimer’s disease dosage is given to the patient 20 mg per day for 3 months. 5 mg dose of donepezil is less incidence than 10 mg dosage of donepezil. But the adverse effect of donepezil is similar to 5 mg and 10 mg.

Before taking Donepezil to take some precaution

The patient must take some care which affects the heart disease , cardiac conduction (some muscle in heart cell are sending the signal to contract the heart), chronic obstructive pulmonary disease, asthma, severe cardiac arrhythmias and sick sinus syndrome(sinus dysfunction)
If any portion is taking NSAIDS or patient suffer the peptic ulcer disease high risk of gastrointestinal bleeding occurs. slow the heartbeat also seen in the patient .this type of symptoms are more when the dose of donepezil is increase 5 mg to 10 mg.

Donepezil price

Eisai pharmaceutical manufacture the Donepezil as the name of ARICEP SR 23 mg 10 Tablets price 350 rupees.
Sun pharmaceutical ltd manufacture the donepezil as name of Donetaz sr 23 mg for 10 tablets price is 250 rupees.
Cipla manufacture the donepezil as the name of DONECEPT 5 mg and 10 mg according to the dose for 10 tablets 108.65 rupees and 150.65 rupees .

Reference: all the information are collected form wikipedia


Popular posts from this blog

Risperidone side effect, mechanism of action,use

Risperidone side effect, mechanism of action, use
What is Risperidone?
Risperidone is medicine use as antipsychotic treatment. Antipsychotic diseases like Schizophenia, bipolar disorder, autism . How to take risperidone Before taking of this drug must read the manual or leaflet which is present along with this medicine. if you are not comforted with this then take the advice of doctor or pharmacist. It is also used for the treating of obsessive-compulsive disorder .in this disease patient are doing the one work repetitively. It also helpful for dementia. But FDA does not approve for the treatment of dementia.

The doctor always prescribe the drug for beater effect of in the patient or cure the patient if you have side effect occurs or any discomfort with this drug contact with your doctor immediately. RISPERIDONE SIDE EFFECT Mainly common side effect are shown movement problem, sleepiness, seeing a problem, constipation, increased weight .serious side effect permanently movement problem othe…

Nifedipine use, Side Effects, Mechanism of action, Dosage and Adverse effect

What is Nifedipine? Nifedipine tablets belongs to the group of medicines called calcium channel blocking agents. IUPAC name of this drug is dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate. This drug is yellow in color and crystalline powder and insoluble in water.

Contents What is Nifedipine?Nifedipine useNifedipine Side EffectsMechanism of actionPharmacokinetics of nifedipine Adverse effects of NifedipineDose of nifedipine Nifedipine use Nifedipine tablets is a calcium channel blocker that blocks calcium to the muscles wall of the heart, allow the muscles to relax and widen to increase blood flow to the heart; making it easier for the heart to pump and function properly. Nifedipine is widely used to treat
High blood pressure
Chronic stable angina
Ruptured aneurysm (a problem caused by a burst blood vessel around the brain) Early labour for pregnant women Raynaud’s phenomenon Anal fissures High altitude pulmonary edema Spasms of esophagus due to cance…

Amlodipine Use, Side Effects, Mechanism Action, Dosage and Many Information

What is Amlodipine?Amlodipine chemical name is 3-Ethyl-5-methyl (±)-2-[(2-aminoethoxy)methyl]-4-(2- chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate, monobenzenesulphonate. This avalible in the market as Amlodipine basilate, which is salt form of the drug.
Contents What is Amlodipine?What Amlodipine use for?Amlodipine Side EffectMechanism of actionPharmacokinetic of amlodipineAmlodipine DosageWarning and precautionInteraction of Amlodipine What Amlodipine use for?Amlodipine tabletuse for the treatment of high blood pressure (hypertension). It is also used for the chest pain due to angina. And also use for other diseases like prinzmental’s, variant angina.
Amlodipine is used in the management of hypertension and coronary arteries disease in people with either stable angina (when people are suddenly get shock or more physical work)vasospastic angina (Which is coronary artery vasospasm) and it is use in case of heart attack but not heart failue. It can be used as single dose or …