Budesonide:side effect ,Use, Mechanism of action , Price,Budesonide Inhaler
What is Budesonide?
Budesonide is comes under corticosteroid . it mainly use for asthma and chronic obstructive pulmonary disease (COPD). It is available as inhaler . pil, nasal spray, rectal form and capsule .Budesonide is mainly use for asthma in the form of inhaler to treatment of allergic rhinitis and nasal polyps.
Budesonide in the inhaler form are more active than the other dosage form.
Budesonide side effect
Budesonide having some side effect
- Nose burning when inhale
- Bleeding form the nose
- Upset stomach
- Dry mouth
- Sore throat
- Bad test in mouth
- Change in mucus
- Blurred vision
When patient are suffer Swelling of the face ,Difficulty for breathing , white marks in the throat, white marks on face or nose, Irregular menstrual periods, acne on face or behavioral changes occur immediately consult with doctor.
Budesonide for long term use It suppress the immunity of persion that why another disease are affect easily.
Budesonide Interaction with some other
Budesonide is react with some other medicine or food and it increase or reduce the bioavailability .
When budesonide tablet or capsule are taken orally with grapefruit juice may double the bioavailability.
Budesonide decrease bioavailability the coneflowers or group of herbaceous flowering plants.
Budesonide absorption also affect when taken with high fat meal.
Budesonide is very potent Drug use so it use very minute concentration for there action
Budesonide mechanism of action
Budesonide binds with glucocorticoid receptor in the bronchi cytoplasm and its allow thr translocation of the complex to the bronchi nucleus where it binds with HDAC2 and CBP receptor.Cbp complex reduce the production of Inflammatory chain may be inhibition of Bronco constriction. HDAC2 complex increase the gene repression which results inhibits the formation of cytokines like ILS , TNF alpha. And it also decrease the activation of inflammatory cells like T-lymphocytes, mast cells.
When ihinibitis of formation cytokine it also reduced airway inflammation and also reduce Bronchospasm , wheezing and coughing .
When it inhibits activation of eosinophil reduce release of cytokines and it alternatively reduced the Bronchospasm , wheezing and coughing .
When suppression of activation of inflammatory cells such as T- lymphocytes, mast cell and macrophages indirectly reduced the Bronchospasm, coughing and wheezing.
Budesonide is a nonhalogenated glucocorticoid with high topical with less systemic effect.it gives to patient in server cases.
Mainly act two procress
Severe chronic asthma
when asthma not controlled by bronchodilators and inhale stroid it gives orally with 20- 60 mg of any corticosteroid daily. Gradually decrease the dose .and finally it gives by inhaler .
Acute asthma exacerbation
When asthma attack it not responding to bronchodilator therapy then high dose of I.V injection of glucocorticosteroid is given to the patients.it act for 6-24 hour.
Budesonide Brand names
Pulmicort is metered-dose inhaler, Budecort metered dose inhalation
Foracort is the combination of formoterol 6 micro mg and budesonide 100 micro mg
Rhinocort , Budenase
Budesonide inhaler price 100 MCG is 266.38 which is manufacture by Lupin ltd.
Budesonide capsule 100 mcg is 62 rupess for 30 capsule .
Price are vary to manufacturing company.